The treatment group also had more males, more people with high BMI, more hypertension. You used an adjusted length of stay for deaths. The treatment group had more people with diabetes who are more likely to die from covid. There are considerable differences between the control and treatment groups in a number of variables known to be highly relevant to covid severity and hence length of stay. Trying to cure stage 4 adenocarcinoma of the colon with a supranormal dose of fruits and vegetables upon hospitalization is similar to the intent here. We should try to prevent aortic aneurysms, chronic renal failure requiring dialysis, gunshot wounds requiring emergency surgery, and acute bowel obstructions from advanced neoplasms. The object should be to keep people out of the hospital. For physicians trained and who are familiar with nutraceutical science the approach taken in this trial would make no sense. These numbers are a combination of both serum AND intracellular vitamin D3 levels that translate much more efficiently into hepatic 25 hydroxylation then giving a massive bolus that takes days, perhaps weeks, to actually undergo first pass metabolism and intracellular absorption. There is observational evidence that vitamin D levels above 20 ng/dL are associated with a reduction in risk of death from coronavirus and levels above 36 ng/dL are associated with a reduction in risk of severe disease. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.Boxes represent median and interquartile range and whiskers extend to the highest and lowest values within 1.5 times the interquartile range of the 25th and 75th percentiles. Median (interquartile range) observation time of the postintervention period was 8.0 (4.0-11.5) days for the vitamin D 3 group and 7.0 (6.0-13.3) days for the placebo group. B, For patients with 25-hydroxyvitamin D deficiency, a single high dose of vitamin D 3 significantly increased 25-hydroxyvitamin D levels compared with placebo (difference, 22.7 ng/mL P < .001). Median (interquartile range) observation time of the postintervention period was 7.0 (4.0-10.0) days for the vitamin D 3 group and 7.0 (5.0-13.0) days for the placebo group. A, For all patients, a single high dose of vitamin D 3 significantly increased 25-hydroxyvitamin D levels compared with placebo (difference, 24.1 ng/mL P < .001).
Serum 25-hydroxyvitamin D levels were measured on the day of randomization (baseline) and on hospital discharge (postintervention).
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